Lamivudine/Zidovudine Side Effects See also Warning section. Anemia, neutropenia, and leukopenia were reported more often with higher doses (1200 to 1500 mg/day) and in patients with advanced HIV disease (especially with poor bone marrow reserve at baseline) and particularly in those with CD4 cell counts less than 100/mm3. Lamivudine / zidovudine systemic 150 mg / 300 mg (TV TV L2 L2), We comply with the HONcode standard for trustworthy health information -, Blistering, peeling, or loosening of the skin, itching, puffiness, or swelling of the eyelids or around the eyes, face, lips, or tongue, muscle pain, spasms, stiffness, or cramping, red skin lesions often with a purple center, sores, ulcers, or white spots in the mouth or on the lips or tongue, tingling, burning, numbness, or pain in the hands, arms, feet, or legs, darkening of the skin and mucous membranes, swelling of the breasts or breast soreness in both females and males, swollen, painful, or tender lymph glands in the neck, armpit, or groin. muscle cramps, pain, stiffness, or spasms, pains in the stomach, side, or abdomen, possibly radiating to the back, puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue, right upper abdominal or stomach pain and fullness, burning, tingling, numbness or pain in the hands, arms, feet, or legs, weight gain around your neck, upper back, breast, face, or waist. Discontinue lamivudine / zidovudine if clinical or laboratory findings suggestive of lactic acidosis or pronounced hepatotoxicity occur.Severe acute exacerbations of hepatitis B have been reported in patients who are co-infected with hepatitis B virus (HBV) and HIV-1 and have discontinued lamivudine. Lamivudine Side Effects See also Warning section. Lactic acidosis and severe hepatomegaly with steatosis (including fatal cases) have been reported with the use of nucleoside analogs. Sahai J, Conway B, Cameron D, Garber G "Zidovudine-associated hypertrichosis and nail pigmentation in an HIV-infected patient." J Am Acad Dermatol 21 (1989): 192-3, 27. Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Continuous Professional Development, Mayo Clinic School of Graduate Medical Education, FREE book offer — Mayo Clinic Health Letter, Time running out - 40% off Online Mayo Clinic Diet ends soon. If any of these effects persist or worsen, tell your doctor or pharmacist promptly. Elevated ALT (greater than 5 x ULN), AST (greater than 5 x ULN), and bilirubin (greater than 2.5 x ULN) have been reported in 3.7%, 1.7%, and 0.8% of patients using lamivudine plus zidovudine, respectively, and 3.6%, 1.8%, and 0.4% of patients using zidovudine, respectively. In an asymptomatic HIV infection study, anorexia was reported in 19.3% (using 1500 mg) and 20.1% (using 500 mg) of patients using zidovudine. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Truvada, tenofovir, lamivudine, emtricitabine, Atripla, Stribild, Complera, Epzicom. In an advanced HIV disease study, rash (17%) and diaphoresis (5%) were reported with zidovudine. Zidovudine has been associated with hematologic toxicity (including neutropenia and severe anemia), particularly in patients with advanced HIV-1 disease. Serious side effects and their symptoms can include the following: Lactic acidosis or severe liver enlargement. O 0, 4. These side effects may go away during treatment as your body adjusts to the medicine. Lamivudine side effects. If you notice any other effects, check with your healthcare professional. 2. hypertriglyceridaemia, hypercholesterolaemia, insulin resistance, hyperglycaemia, hyperlactataemia), osteonecrosis; … The most serious side include muscle pain, liver failure, pancreatitis, and liver failure. [Ref], Common (1% to 10%): Anorexia and/or decreased appetite, Postmarketing reports: Hyperglycemia, redistribution/accumulation of body fat, lactic acidosis, -Very rare (less than 0.01%): Lactic acidosis, -Postmarketing reports: Hyperlactatemia (common), lactic acidosis (rare), redistribution/accumulation of body fat, -Rare (0.01% to 0.1%): Lactic acidosis (without hypoxemia), -Frequency not reported: Redistribution/accumulation of body fat, hyperlactatemia, -Frequency not reported: Redistribution/accumulation of body fat (including central obesity, dorsocervical fat enlargement, peripheral wasting, facial wasting, breast enlargement, "cushingoid appearance"), increased blood lipid levels, increased glucose levels[Ref], Common (1% to 10%): Skin rashes, sweating, fungal skin infection, acne and folliculitis, viral skin infection, Postmarketing reports: Alopecia, erythema multiforme, Stevens-Johnson syndrome, urticaria, -Common (1% to 10%): Sweating/diaphoresis, fungal skin infection, acne and folliculitis, viral skin infection, -Rare (0.01% to 0.1%): Nail and skin pigmentation, urticaria, -Frequency not reported: Lipoatrophy, skin and nailbed pigmentation changes, toxic epidermal necrolysis, leukocytoclastic vasculitis (with eosinophilia and fever), nail hyperpigmentation (rarely accompanied by mucocutaneous pigmentation or hypertrichosis), body odor[Ref]. All rights reserved. Am J Med 86 (1989): 469-70, 26. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Discoloration has occurred as longitudinal streaks or transverse bands. [Ref], Very common (10% or more): Musculoskeletal pain (up to 13.5%), Postmarketing reports: Muscle weakness, elevated creatine phosphokinase (CPK), rhabdomyolysis, -Common (1% to 10%): Arthralgia, muscle disorders, -Common (1% to 10%): Musculoskeletal pain, myalgia, -Frequency not reported: Symptomatic myopathy, myositis, back pain, arthralgia, muscle spasm, twitch, -Frequency not reported: Osteonecrosis[Ref]. It contains lamivudine, nevirapine, and stavudine. Our general interest e-newsletter keeps you up to date on a wide variety of health topics. Side effects: 77. It is much better tolerated than interferon. Epivir (lamivudine)." Zidovudine has been associated with hematologic toxicity including neutropenia and severe anemia, particularly in patients with advanced Human Immunodeficiency Virus (HIV-1) disease.Prolonged use of zidovudine has been associated with symptomatic myopathy.Lactic acidosis and severe hepatomegaly with steatosis, including fatal cases, have been reported with the use of nucleoside analogues, including lamivudine and zidovudine. Tell your doctor if you have: signs of a new infection --fever, night sweats, swollen glands, cold sores, cough, wheezing, diarrhea, weight loss; Aids 14 (2000): 1309-16, 13. All rights reserved. In this study, seizures, vertigo, hearing loss, hyperalgesia, tremor, and syncope were reported in less than 5% of patients using zidovudine. Dolutegravir & Abacavir & Lamivudine - Get up-to-date information on Dolutegravir & Abacavir & Lamivudine side effects, uses, dosage, overdose, pregnancy, alcohol and more. Glaxo Wellcome, Research Triangle Park, NC. As of 2019, it is listed by the World Health Organization (WHO) as the first line treatment for adults with HIV/AIDS, with tenofovir/lamivudine/efavirenz as an alternative. JAMA 260 (1988): 3587-8, 18. "Tolerability of postexposure prophylaxis with the combination of zidovudine-lamivudine and lopinavir-ritonavir for HIV infection." A rare and potentially fatal condition called lactic acidosis can develop in patients taking lamivudine. "Product Information. Serious side effects can occur with lamivudine use. Cerner Multum, Inc. "Australian Product Information." Other side effects include: neutropenia. Clin Infect Dis 40 (2005): 303-5, 10. In fact, in at least one trial, the lamivudine had fewer side effects than the placebo pills. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Medical uses. Medically reviewed by Drugs.com. Ann Intern Med 112 (1990): 145-6, 28. AIDS 12 (1998): 1735-44. Ann Intern Med 116 (1992): 311-3. Although rare, they may require the immediate termination of the drug and, in some cases, emergency medical intervention. Many people using this medication do not have serious side effects. Pharmacotherapy 26 (2006): 1111-33, 12. Occasionally, neutropenia and anemia reported with lamivudine were severe. pregnancy, upcoming surgery, etc. Data sources include IBM Watson Micromedex (updated 3 Mar 2021), Cerner Multum™ (updated 1 Mar 2021), ASHP (updated 3 Mar 2021) and others. Herskowitz A, Willoughby SB, Baughman KL, et al "Cardiomyopathy associated with antiretroviral therapy in patients with HIV infection: a report of six cases." In an advanced HIV disease study, headache (42%), somnolence (8%), dizziness (6%), paresthesia (6%), and taste perversion (5%) were reported with zidovudine; only headache was reported at a significantly greater rate than placebo. These side effects may go away during treatment as your body adjusts to the medicine. AIDS 13 (1999): 1659-67, 14. Rabaud C, Burty C, Grandidier M, et al. In this study, anxiety, confusion, depression, emotional lability, nervousness, and loss of mental acuity were reported in less than 5% of patients using zidovudine. Exacerbation of anemia has been reported in HIV-1/HCV-coinfected patients using zidovudine and ribavirin. Elevated amylase (greater than 2 times the upper limit of normal [2 x ULN]) has been reported in 4.2% of patients using lamivudine plus zidovudine and 1.5% of patients using zidovudine. [Ref], Common (1% to 10%): Elevated ALT, elevated AST, abnormal liver function tests, Uncommon (0.1% to 1%): Elevated bilirubin, Frequency not reported: Severe hepatomegaly with steatosis, hepatic decompensation, Postmarketing reports: Hepatic steatosis, posttreatment exacerbation of hepatitis B, -Uncommon (0.1% to 1%): Elevated liver enzymes (AST, ALT), -Rare (0.01% to 0.1%): Hepatitis, abnormal liver function tests, -Common (1% to 10%): Elevated liver enzyme levels in blood (including ALT, AST), elevated bilirubin levels in blood, -Rare (0.01% to 0.1%): Liver disorders (e.g., severe hepatomegaly with steatosis), -Frequency not reported: Changes in liver function tests (including increased AST levels), acute hepatic failure[Ref], Common (1% to 10%): Neutropenia, anemia, lymphatic signs/symptoms, decreased white cells, Postmarketing reports: Anemia (including pure red cell aplasia and anemias progressing on therapy), lymphadenopathy, splenomegaly, -Uncommon (0.1% to 1%): Neutropenia, anemia, thrombocytopenia, decreased white cells, -Very rare (less than 0.01%): Pure red cell aplasia, -Very common (10% or more): Granulocytopenia, anemia, -Common (1% to 10%): Neutropenia, leukopenia, lymphatic signs/symptoms, decreased white cells, thrombocytopenia, -Uncommon (0.1% to 1%): Pancytopenia (with marrow hypoplasia), -Rare (0.01% to 0.1%): Pure red cell aplasia, -Very rare (less than 0.01%): Aplastic anemia, -Frequency not reported: Exacerbation of anemia, hemolytic anemia, hematologic toxicity (including neutropenia, severe anemia), lymphadenopathy[Ref]. AIDS 21 (2007): 268-269, 11. 8. In an asymptomatic HIV infection study, nausea, vomiting, and constipation were reported in 57.3%, 16.4%, and 8.1% (using 1500 mg) and 51.4%, 17.2%, and 6.4% (using 500 mg) of patients using zidovudine, respectively.[Ref]. It is taken by mouth twice a day. In the early symptomatic HIV disease study, nausea (61%), vomiting (25%), and dyspepsia (6%) were reported with zidovudine. Tell your doctor if you have unlikely but serious side effects of Combivir including: mental/mood changes (such as depression), signs of pancreatitis (such as vomiting, stomach/abdominal/ back pain, fever), easy bruising or bleeding, or Combivir (lamivudine-zidovudine)" Glaxo Wellcome, Research Triangle PK, NC. If appropriate, initiation of anti-hepatitis B therapy may be warranted. Drug information provided by: IBM Micromedex. In this study, redistribution/accumulation of body fat was reported in less than 5% of patients using zidovudine. For Healthcare Professionals General. Hepatic decompensation (some fatal) has been reported in patients coinfected with HIV-1 and hepatitis C virus (HCV) receiving combination antiretroviral therapy for HIV-1 and interferon alfa with or without ribavirin. Incidence of neutropenia increased in patients with low neutrophil counts, hemoglobin levels, and serum vitamin B12 levels at baseline. 2014;127(14):2632-6. You may report side effects to FDA at 1-800-FDA-1088. Bluish or brownish-black discoloration of nails has developed during the first 1 or 2 months of zidovudine therapy and usually disappeared within 2 months if the drug is discontinued. Incidence was higher in patients with mild laboratory abnormalities at baseline. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Other side effects not listed may also occur in some patients. [Ref], In an advanced HIV disease study, vasodilation was reported in less than 5% of patients using zidovudine. "Product Information. Serious side effects of lamivudine include a buildup of lactic acid in the blood (lactic acidosis), severe liver problems, and inflammation of the pancreas (pancreatitis) in children at risk for developing pancreatitis. 7. Available for Android and iOS devices. Many other medications may also interact with lamivudine and zidovudine, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list. Don P, Fusco F, Fried P, et al "Nail dyschromia associated with zidovudine." Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Some side effects may occur that usually do not need medical attention. Neutropenia (absolute neutrophil count less than 750/mm3), anemia (hemoglobin less than 8 g/dL), and thrombocytopenia (platelets less than 50,000/mm3) have been reported in 7.2%, 2.9%, and 0.4% of patients using lamivudine plus zidovudine, respectively, and 5.4%, 1.8%, and 1.3% of patients using zidovudine, respectively. See "Lamivudine Precautions" section. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. You may report them to the FDA. [Ref], -Frequency not reported: Urinary hesitancy, dysuria, polyuria[Ref]. pains in the stomach, side, or abdomen, possibly radiating to the back pinpoint red spots on the skin puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue right upper abdominal or stomach pain and fullness Ann Intern Med 117 (1992): 487-501, 20. Pharmacokinetics: Absorption: Rapidly absorbed from the GI tract.Delayed absorption by ingestion w/ food. Minor side effects may include nausea, fatigue, headaches, diarrhea, cough and nasal congestion. Schedule your appointment now for safe in-person care. Gastro-intestinal disorders: Pancreatitis, upper abdominal pain, … Description: Lamivudine, a synthetic nucleoside analogue, is phosphorylated into the body to the active 5'-triphosphate metabolite.It inhibits RNA- and DNA-dependent polymerase activities of reverse transcriptase via DNA chain termination. Expert Rev Anti Infect Ther 2 (2004): 826, 24. Lamivudine affects your immune system, which may cause certain side effects (even weeks or months after you've taken this medicine). Muscle biopsy has shown atrophic and sometimes necrotic fibers, ragged-red fibers, and large accumulations of mitochondrial and fibrillar sarcoplasmic inclusions. McLeod GX, Hammer SM "Zidovudine: five years later." In an asymptomatic HIV infection study, asthenia and malaise were reported in 10.1% and 55.6% (using 1500 mg) and 8.6% and 53.2% (using 500 mg) of patients using zidovudine, respectively. Rarely, lamivudine and zidovudine have caused severe (sometimes fatal) liver problems and a certain metabolic problem (lactic acidosis). This site complies with the HONcode standard for trustworthy health information: verify here. Commonly reported side effects include: headache; ear, nose or throat infections; sore throat; malaise (general ill feeling) and fatigue; nausea; diarrhea; cough; fever; chills; muscle and joint pain; This is not a complete list of lamivudine side effects. Panel on Antiretroviral Guidelines for Adults and Adolescents "Guidelines for the use of antiretroviral Taking efavirenz, lamivudine, and tenofovir at bedtime may make certain side effects less bothersome. See below for a comprehensive list of adverse effects. Gradon JD, Chapnick EK, Sepkowitz DV "Zidovudine-induced hepatitis." SaintMarc T, Partisani M, PoizotMartin I, Bruno F, Rouviere O, Lang JM, Gastaut JA, Touraine JL "A syndrome of peripheral fat wasting (Lipodystrophy) in patients receiving long-term nucleoside analogue therapy." In the early symptomatic HIV disease study, asthenia was reported in 69% of patients using zidovudine. Anemia (hemoglobin less than 8 g/dL) has been reported in 6.4% (CD4 up to 500 using 1500 mg), 1.1% (CD4 up to 500 using 500 mg), 4% (CD4 greater than 200 using 1200 mg), 3% (CD4 greater than 200 using 1500 mg), and 29% (CD4 less than 200 using 1500 mg) of patients using zidovudine. 5. Along with its needed effects, a medicine may cause some unwanted effects. [Ref], Very common (10% or more): Malaise and fatigue (27%); ear, nose, and throat infection (up to 11.3%), Common (1% to 10%): Fever or chills; viral ear, nose, and throat infection; viral infection, -Common (1% to 10%): Fatigue, malaise, fever, -Very common (10% or more): Asthenia, fever, malaise, -Common (1% to 10%): Ear, nose, and throat infection; viral ear, nose, and throat infection; viral infection, -Rare (0.01% to 0.1%): Chills, chest pain, influenza-like syndrome, -Frequency not reported: Influenza syndrome, -Frequency not reported: Increased weight[Ref], Very common (10% or more): Nasal signs and symptoms (20%), cough (18%), throat and tonsil discomfort and pain (up to 11.6%), Common (1% to 10%): Bronchitis, sinusitis, breathing disorders, upper respiratory inflammation, Frequency not reported: Dyspnea, rhinitis, Postmarketing reports: Abnormal breath sounds/wheezing, -Common (1% to 10%): Cough, nasal symptoms, -Common (1% to 10%): Throat and tonsil discomfort and pain, sinusitis, bronchitis, breathing disorders, upper respiratory inflammation, dyspnea, -Frequency not reported: Epistaxis, pharyngitis, rhinitis, hoarseness[Ref], In an advanced HIV disease study, dyspnea (5%) was reported with zidovudine. Portions of this document last updated: Feb. 01, 2021. pains in the stomach, side, or abdomen, possibly radiating to the back pinpoint red spots on the skin puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue right upper abdominal or stomach pain and fullness Incidence was higher in patients with mild laboratory abnormalities at baseline. In an advanced HIV disease study, myalgia (8%) was reported with zidovudine at a significantly greater rate than placebo. Side effects have been reported with lamivudine and zidovudine, administered separately or together. Epivir (lamivudine) side effects list for healthcare professionals The following adverse reactions are discussed in other sections of the labeling: Exacerbations of hepatitis B. Lactic acidosis and severe hepatomegaly with steatosis. "New once-daily HIV combination better tolerated." Nervous system. Headache, tiredness, loss of appetite, nausea, vomiting, diarrhea, trouble sleeping, dizziness, or stuffy nose may occur. Arch Intern Med 151 (1991): 981-6, 17. Rarely, lamivudine has caused severe (sometimes fatal) liver problems and a buildup of lactic acid in the blood (lactic acidosis). In an advanced HIV disease study, lymphadenopathy was reported in less than 5% of patients using zidovudine.[Ref]. Check out these best-sellers and special offers on books and newsletters from Mayo Clinic. AIDS 5 (1991): 1395-6, 25. Merenich JA, Hannon RN, Gentry RH, Harrison SM "Azidothymidine-induced hyperpigmentation mimicking primary adrenal insufficiency." (4/8/2015): 6. In an advanced HIV disease study, anorexia (11%) was reported with zidovudine. 9. O'Dowd MA, McKegney FP "Manic syndrome associated with zidovudine." Take efavirenz, lamivudine, and tenofovir exactly as directed. It is either used by itself or along with other antiretrovirals. Wright JM, Sachdev PS, Perkins RJ, Rodriguez P "Zidovudine-related mania." Puro V, Soldani F, De Carli G, Lazarevic Z, Mattioli F, Ippolito G "Drug-induced aminotransferase alterations during antiretroviral HIV post-exposure prophylaxis." Redistribution/accumulation of body fat has been reported with antiretroviral therapy; causality has not been established. vitamins, herbal supplements, etc. In this study, back pain, arthralgia, muscle spasm, twitch, and myopathy were reported in less than 5% of patients using zidovudine. [Ref], Very common (10% or more): Headache (up to 35.1%), neuropathy (up to 12.4%), dizziness (up to 10.4%), Frequency not reported: Syncope, taste perversion, Postmarketing reports: Paresthesia, peripheral neuropathy, seizures, -Rare (0.01% to 0.1%): Peripheral neuropathy/neuropathy, paresthesia, -Very common (10% or more): Headache, dizziness, -Common (1% to 10%): Neuropathy, paresthesia, somnolence, taste perversion, -Frequency not reported: Generalized seizures, status epilepticus, vertigo, Wernicke's syndrome, hearing loss, hyperalgesia, tremor, syncope[Ref], Very common (10% or more): Nausea (33%), diarrhea (18%), nausea and vomiting (13%), abdominal discomfort and pain (up to 11.3%), Common (1% to 10%): Abdominal cramps, dyspepsia, elevated amylase, fungal gastrointestinal (GI) infection, GI discomfort and pain, gaseous symptoms, vomiting, Postmarketing reports: Oral mucosal pigmentation, stomatitis, pancreatitis, -Common (1% to 10%): Nausea, vomiting, abdominal discomfort and pain or cramps, diarrhea, -Uncommon (0.1% to 1%): Pancreatitis, abnormal pancreatic enzymes, -Rare (0.01% to 0.1%): Elevated serum amylase, -Very common (10% or more): Nausea, GI pain, diarrhea, vomiting, -Common (1% to 10%): Abdominal discomfort and pain, fungal GI infection, GI discomfort and pain, gaseous symptoms, elevated amylase, dyspepsia, -Rare (0.01% to 0.1%): Oral mucosa pigmentation, pancreatitis, -Frequency not reported: Constipation, dysphagia, tongue edema, eructation, bleeding gums, rectal hemorrhage, lip edema, mouth ulcer[Ref]. Lamivudine / 3TC TABLETS AND ORAL SOLUTION. Side Effects . [Ref], Postmarketing reports: Cardiomyopathy, vasculitis, -Frequency not reported: Vasodilation[Ref], Frequency not reported: Immune reconstitution/reactivation syndrome, autoimmune disorders in the setting of immune reconstitution (e.g., Graves' disease, polymyositis, Guillain-Barre syndrome), Frequency not reported: Disturbances of vision, -Frequency not reported: Amblyopia, photophobia, macular edema[Ref]. Incidence was higher in patients with mild laboratory abnormalities at baseline. Although not all of these side effects may occur, if they do occur they may need medical attention. The most common side effects of DOVATO include: headache; nausea; diarrhea; trouble sleeping; tiredness; anxiety; These are not all the possible side effects of DOVATO. Myopathy and myositis (with pathological changes similar to that produced by HIV-1 disease) have been associated with prolonged zidovudine use. Gallant JE, DeJesus E, Arribas JR, et al "Tenofovir DF, emtricitabine, and efavirenz vs. zidovudine, lamivudine, and efavirenz for HIV." In this study, cough, epistaxis, pharyngitis, rhinitis, sinusitis, and hoarseness were reported in less than 5% of patients using zidovudine. Lamivudine and zidovudine affects your immune system, which may cause certain side effects (even weeks or months after you've taken this medicine). Mayo Clinic does not endorse companies or products. For many of these side effects, it was not clear if they were due to lamivudine, zidovudine, the other drugs used to treat HIV infection, or the underlying disease process.[Ref]. "Severe liver toxicity in postexposure prophylaxis for HIV infection with a zidovudine, lamivudine and fosamprenavir/ritonavir regimen." In an advanced HIV disease study, asthenia (19%), fever (16%), and malaise (8%) were reported with zidovudine. Get medical help right away if you have any of the following serious symptoms, including: symptoms of liver problems (such as … ), allergies, pre-existing diseases, and current health conditions (e.g. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Applies to lamivudine / zidovudine: oral tablet, Side effects have been reported with lamivudine and zidovudine, administered separately or together. Pavel S, Burty C, Alcaraz I, et al. Dubin G, Braffman MN "Zidovudine-induced hepatotoxicity." HCPs who received occupational PEP with triple-drug regimen, AZT+3TC+Lpv/r, experienced different side effects, and the tolerability and safety of PEP regimen were good in this cohort. Common Questions and Answers about Lamivudine side effects. These side effects may go away during treatment as your body adjusts to the medicine. [Ref], Postmarketing reports: Sensitization reactions (including anaphylaxis), -Frequency not reported: Sensitization reactions (including anaphylaxis)[Ref], In an advanced HIV disease study, urinary frequency, urinary hesitancy, dysuria, and polyuria were reported in less than 5% of patients using zidovudine. Headache, dizziness, nausea, diarrhea, or trouble sleeping may occur. Glaxo Wellcome, Research Triangle Park, NC. Applies to lamivudine/zidovudine: oral tablet. At least 1 case of macular edema was deemed definitively associated with zidovudine in a patient with history of anterior uveitis secondary to syphilis. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. License: Except as otherwise noted, this work is licensed under a Creative Commons Attribution-Noncommercial-Share Alike 4.0 License.For commercial use or customized versions, please contact biobyte solutions GmbH.. Disclaimer: The content of this database of side effects (adverse drug reactions) is intended for educational and scientific research purposes only.
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