BRIEF REVIEWS Signal Transduction b Calcitonin and kidney. Background: Calcitonin gene-related peptide (CGRP) can protect against hyperoxia-induced lung injury, making the upregulation of CGRP a potential therapeutic approach for this type of injury. The potential of CGRP to act on many different receptors with differing affinities and efficacies makes deciphering the signalling from the CGRP receptor a challenging task for researchers. Abstract. The Calcitonin Secretion Pathway complements our catalog of research reagents including antibodies and ELISA kits against CALCA, PTH, PTRH1, SST, GCG. Calcitonin Secretion Bioinformatics Tool Laverne is a handy bioinformatics tool to help facilitate scientific exploration of related genes, diseases and pathways based on co-citations. To examine how the PKA and PKC pathways are involved in the effects of calcitonin, we focused on changes in the cytoskeleton of murine osteoclast-like multinucleated cells (OCLs) formed in vitro. Exogenous CGRP upregulates profibrogenic growth factors through PKC/JNK signaling pathway in kidney proximal tubular cells. Signaling capability of the calcitonin receptor (CTR), showing some of the major intracellular signaling pathways that are activated on binding of calcitonin (CT) to the CTR. Recently, it was reported that calcitonin receptors were coupled to both cAMP-dependent protein kinase (PKA) and protein kinase C (PKC). Author information: (1)Department of Anatomy, Jeju National University School of Medicine, 102 Jejudaehak-ro, Jeju, 63243, Republic of Korea. 1996; 137 : 4685-4690 View in Article Although discussion of the biology of CT in this review is necessarily Multiple Ligands, Receptors, and Signaling limited, an excellent in-depth treatment Pathways can be found elsewhere (Azria 1989). Calcitonin is a 32 amino acid peptide hormone secreted by parafollicular cells (also known as C cells) of the thyroid gland in humans, and in many other animals in the ultimopharyngeal body. adrenomedullin, adrenomedullin 2 (intermedin), amylin, calcitonin and calcitonin gene-related peptides (CGRPs)) combining with a calcitonin family receptor on the surface of the … The experiments showed that strontium biases CaSR signaling toward ERK1/2 signaling and possibly another pathway independent of G(q/11) signaling and [Ca(2+)](i) mobilization. Standard name: GO_CALCITONIN_FAMILY_RECEPTOR_SIGNALING_PATHWAY: Systematic name: M24784: Brief description: A series of molecular signals initiated by an extracellular member of the calcitonin family (e.g. Calcitonin gene-related peptide (CGRP) is a promiscuous peptide, similar to many other members of the calcitonin family of peptides. The calcitonin receptor (CT) is a G protein-coupled receptor that binds the peptide hormone calcitonin and is involved in maintenance of calcium homeostasis, particularly with respect to bone formation and metabolism.. CT works by activating the G-proteins G s and G q often found on osteoclasts, on cells in the kidney, and on cells in a number of regions of the brain. Like other GPCRs which can form homodimers or heterodimers, the CTR can also form dimers, and probably greater aggregates, which may have consequences for their cellular localization and function. It is noteworthy that the potency of strontium-stimulated calcitonin secretion was elevated compared with calcium. It acts to reduce blood calcium (Ca 2+), opposing the effects of parathyroid hormone (PTH). However, the effects of CGRP on the Wnt7b/β-catenin signaling pathway are unclear. Yoon SP(1)(2), Kim J(3)(4). Calcitonin-induced changes in the cytoskeleton are mediated by a signal pathway associated with protein kinase A in osteoclasts. Endocrinology.
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