Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. You might need to measure your blood pressure at home. This medicine may cause your blood sugar levels to rise or fall. It also works to slow or stop tumor growth in patients with neuroendocrine tumors and treat carcinoid syndrome. By inhibiting intracellular cyclic AMP and Ca2+ and by a receptor-linked distal effect on exocytosis, SSTRs block cell secretion 3. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. It is given as a shot under your skin or muscle, or as a needle placed into one of your veins. It may not be specific to Sandostatin. Its analogues have been developed to achieve more favourable kinetics for efficiency use in the management of acute conditions, such as esophageal varices. Octreotide lowers many substances in the body such as insulin and glucagon (involved in regulating blood sugar), growth hormone, and chemicals that affect digestion. For the symptomatic treatment of acute bleeding from esophageal varices. The presence of other medical problems may affect the use of this medicine. Somatostatin Analogs. Drug type: Octreotide is hormone drug that is used to treat some types of cancer. Ask your doctor or pharmacist … See Prices. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The serum concentration of Acenocoumarol can be increased when it is combined with Somatostatin. If necessary, the kit may be re-refrigerated. Your doctor may decide not to treat you with this medication or change some of the other medicines you take. SSTRs 1 to 4 bind both somatostatin isoforms with equal nanomolar binding affinity whereas SSTR5 exhibits a 5- to 10-fold higher binding affinity for SST-28 1. Talk to your doctor if you have concerns. This medicine may increase your risk for heart and blood vessel problems, including hypertension and a slow heartbeat. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. If you are using this medicine at home, your doctor or nurse will teach you how to prepare and inject the medicine. Follow your doctor's orders or the directions on the label. Following intravenous administration of 3H-labeld endogenous somatostatin, the total body clearance was approximately 50 mL/min 5. Select one or more newsletters to continue. Somatostatin is an endogenous peptide hormone that is secreted by the central nervous system, gastrointestinal tract, retina, peripheral neurons and pancreatic D cells of the islets of Langerhans. Gallbladder problems (>60%): Decreased gallbladder contractility, gallstones, cholecystitis, cholestatic hepatitisDysglycemia (25%)Hypothyroidism (25%)Bradycardia (25%) It exhibits several biological roles but predominantly exerts an inhibitory effect on secretion of other hormones and transmitters 1. However, the dose is usually not more than 450 mcg per day. Adult 3.5 mcg/kg body wt/hr as continuous IV infusion of 250 mcg/hr. Put used needles and syringes in a puncture-resistant disposable container or dispose of them as directed by your doctor. Octreotide Acetate Injection, a cyclic octapeptide prepared as a clear colorless sterile solution of Octreotide, acetate salt, in a buffered acetic acid solution for administration by deep subcutaneous (intrafat) or intravenous injection. 1992 Sep;43(1-3):27-35. Somatostatin binds to 5 subtypes of somatostatin receptors (SSTRs), which are all Gi-protein-coupled transmembrane receptors that inhibits adenylyl cyclase upon activation 1. This medicine may increase your risk of having gallstones, which may lead to swelling of the gallbladder (cholecystitis), bile ducts (cholangitis), or pancreas (pancreatitis). Liver disease—Use with caution. Rx. Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. [, Patel YC: Somatostatin and its receptor family. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements. Store in the refrigerator. Somatostatin is part of the drug class: Somatostatin and analogues; Somatostatin Interactions. This medicine may improve fertility in women and may cause unwanted pregnancies. Anterior pituitary gland and brain: It inhibits the release of growth hormones and thyroid-stimulating hormones, such as thyroid stimulating hormone (TSH) and thyrotrophin, from the anterior pituitary while inhibiting the release of dopamine from the midbrain, norepinephrine, TRH and corticotrophin-releasing hormone in the brain 1. Description: Somatostatin is a polypetide obtained synthetically or from the hypothalamus.It acts by inhibiting the release of growth hormone from the anterior pituitary. SSTR3 triggers PTP-dependent cell apoptosis accompanied by activation of p53 and the pro-apoptotic protein Bax 3. Call your doctor for medical advice about side effects. SANDOSTATIN prescription and dosage sizes information for physicians and healthcare professionals. severe stomach pain with nausea and vomiting, changes in skin color, pain, tenderness, swelling of the foot or leg, fast, irregular, pounding, or racing heartbeat or pulse, increased menstrual flow or vaginal bleeding, itching, pain, redness, swelling, tenderness, or warmth on the skin, paleness or cold feeling in the fingertips and toes, puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue, swelling of the face, fingers, feet, or lower legs, tingling or pain in the fingers or toes when exposed to cold temperatures, pains in the stomach, side, or abdomen, possibly radiating to the back, excess air or gas in the stomach or bowels, pain, redness, stinging, swelling, tingling, or burning sensation at the injection site, redness of the face, neck, arms and occasionally, upper chest, Absent, missed, or irregular menstrual periods, feeling of constant movement of self or surroundings, numbness or tingling of the hands, feet, or face, swelling of the breasts or breast soreness in both females and males, thick, white vaginal discharge with no odor or with a mild odor, unexpected or excess milk flow from the breasts. Somatostatin is initially secreted as a 116 amino acid precursor, preprosomatostatin, which undergoes endoproteolytic cleavage to prosomastatin. Injecting the medicine after it has been warmed to room temperature rather than cold from the refrigerator may reduce the discomfort. Drug class: Somatostatin Analogues LANREOTIDE is used to reduce blood levels of growth hormone in patients with a condition called acromegaly . Emd Serono, A Division Of Emd Inc., Canada, Injection, powder, lyophilized, for solution, Injection, powder, for solution; injection, powder, lyophilized, for solution, Synthetic growth hormone release-inhibiting hormone, Rai U, Thrimawithana TR, Valery C, Young SA: Therapeutic uses of somatostatin and its analogues: Current view and potential applications. Generic Name: octreotide (ok-TREE-oh-tide) (Injection route, Intramuscular route, Subcutaneous route). Somavert, Somatuline Depot, Sandostatin LAR Depot, bromocriptine, octreotide, lanreotide, Parlodel, Mycapssa. This information should not be interpreted without the help of a healthcare provider. Keep track of where you give each shot to make sure you rotate body areas. Epub 2015 May 5. 8 Additionally, it is used for the treatment of acromegaly and symptoms arising from various tumors, including carcinoid tumors and vasoactive intestinal tumors (VIPomas). Children—Use and dose must be determined by your doctor. Acromegaly is characterized as the endocrine disorder caused by a functioning tumour of cells that secrete growth hormone from the anterior pituitary 9. Octreotide injection is used to treat severe diarrhea and other symptoms that occur with certain intestinal tumors or metastatic carcinoid tumors (tumors that has already spread in the body). If your dose is different, do not change it unless your doctor tells you to do so. These side effects may go away during treatment as your body adjusts to the medicine. Do not reuse needles and syringes. It is very important that your doctor check your progress closely while you are receiving this medicine to make sure that this medicine is working properly. CLASSES. From Lewis S. Blevins, Jr. MD – Somatostatin analogs are a class of drugs that are chemically modified forms of native somatostatin. Pain. Its actions are spread to different parts of the body. Somatostatin, also known as growth hormone-inhibiting hormone, is a naturally-occurring peptide hormone of 14 or 28 amino acid residues 9 that regulates the endocrine system. You may report side effects to the FDA at 1-800-FDA-1088. Somatostatin Drug Class. Side effects, drug interactions, warnings, precautions, dosing, storage, pregnancy, and breastfeeding safety information is provided. Sex Hormones and Insulins, Gastric Cancer After D2 Lymph Node Dissection, Vasoconstrictor Choice on Acute Variceal Bleeding. However, the dose is usually not more than 1500 mcg per day. By binding to SST2 receptors, somatostatin exerts paracrine inhibitory actions on gastrin release from G cells, histamine release from ECL cells, and directly on parietal cell acid output 9. Safety and efficacy have not been established in children younger than 6 years of age. Other treatment options for long-term management of the condition may be considered if necessary, once initial control has been established. This suggests that rapid enzymatic breakdown in the circulation and other tissues serves as a critical route of elimination 5. You must use an effective form of birth control to keep from getting pregnant. Appropriate studies have not been performed on the relationship of age to the effects of the short-acting form of octreotide injection in the pediatric population. It is secreted by the D cells of the islets to inhibit the release of insulin and glucagon, and is also generated in the hypothalamus, where it inhibits the release of growth hormone and thyroid-stimulating hormones from the anterior pituitary 9. Edinburgh: Elsevier/Churchill Livingstone. Drug class: Somatostatin Analogues. The dose of this medicine will be different for different patients. We comply with the HONcode standard for trustworthy health information -, Drug class: somatostatin and somatostatin analogs, Cholangitis (inflammation or swelling of the bile duct) or, Heart rhythm problems (eg, arrhythmia, QT prolongation, slow heartbeat) or, Pancreatitis (inflammation or swelling of the pancreas) or. Sandostatin (octreotide) is a member of the somatostatin and somatostatin analogs drug class and is commonly used for Acromegaly, Carcinoid Tumor, and Vasoactive Intestinal Peptide Tumor. $9,401. 2001 Feb 15;90(3):233-44. Octreotide works by reducing the amount of growth hormone that is produced by the body. Pharmacology, adverse reactions, warnings and side effects. Drug/Laboratory Test Interactions. Do not keep outdated medicine or medicine no longer needed. Blood and urine tests may be needed to check for unwanted effects. Keep this container away from children and pets. Advertisement. Effects of SSTR4: The functions of SSTR4 remain largely unknown 1. If you notice any other effects, check with your healthcare professional. In the vascular system this likely produces vasoconstriction by inhibiting adenylate cyclase leading to a lowering the concentration of cyclic adenosine monophosphate in the endothelial cells which ultimately blocks vasodilation through this pathway. See All 5 Drugs. Eye/retina: Somatostatin inhibits the production of vascular endothelial growth factor 1. Effects of SSTR1: Upon biding of somatostatin and activation, SSTR1 mediates an antisecretory effect on growth hormone, prolactin and calcitonin 1. No known interference exists with clinical laboratory tests, including amine or peptide determinations. Adults—At first, 100 to 600 micrograms (mcg) per day, given in 2 to 4 divided doses, injected under the skin for the first 2 weeks. Somatostatin and analogs. [, 29, 30, 32, 33, 41, . In these cases, your doctor may want to change the dose, or other precautions may be necessary. Check with your doctor right away if you have severe stomach pain with nausea and vomiting, indigestion, fever, chills, pains in the stomach, side, or abdomen, possibly radiating to the back, fast heartbeat, dark urine, bloating, or yellow eyes or skin. This medication is classified as a somatostatin analog. Somatostatin analogues are a … If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Sandostatin ( octreotide) is a man-made protein that is similar to a hormone in the body called somatostatin. Diabetes—Octreotide may cause high or low blood sugar. Drug Abuse And Dependence. Please read with care. The metabolism of Abemaciclib can be decreased when combined with Somatostatin. Somatostatin is a ubiquitous hormone present in […] There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Your doctor will adjust your dose as needed and tolerated. If you believe you are experiencing an interaction, contact a healthcare provider immediately. Do not take other medicines unless they have been discussed with your doctor. As a polypeptide chain, somatostatin is primarily eliminated via metabolism by peptidase enzymes 1. Somatostatin is a hormone produced by the hypothalamus and some other tissues such as the pancreas and the gastrointestinal tract. This medicine usually comes with patient information or directions. Endocrinology. Sandostatin levels in the central nervous system are negligible, even after doses up to 30,000 mcg. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding. In vitro, somatostatin inhibited epidermal growth factor (EGF)-induced DNA synthesis and replication following which suggest that somatostatin may have direct anti-proliferative effects via SSTR signalling 4. (2012). This result in membrane hyperpolarization and inhibits depolarization-induced Ca2+ influx through voltage-sensitive Ca2+ channels 1. If you miss a dose of the long-acting form of this medicine, contact your doctor. In Rang and Dale's Pharmacology (7th ed., pp. This medicine may also be given at home to patients who do not need to be in a medical facility. Last updated on Nov 22, 2020. It does not cure the tumor but it helps the patient feel more comfortable. Effects of SSTR2: SSTR2 subtype dominates in endocrine tissues. Octreotide acetate (Sandostatin, Sandostatin LAR) is an injectable drug prescribed to treat certain people with acromegaly and to treat severe diarrhea and flushing caused by some hormone-secreting cancers. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Trends Endocrinol Metab. Somatostatin also decreases the release of most gastrointestinal hormones and reduces gastric acid and pancreatic secretion. DEA CLASS. The metabolism of Aminophylline can be decreased when combined with Somatostatin. The common pathway shared by the receptors involve the activation of phosphotyrosine phosphatase (PTP), and modulation of mitogen-activated protein kinase (MAPK) 3. While distribution of two active isoforms of somatostatin is similar, SST-14 is more predominant in the enteric neurons and peripheral nerves whereas SST-28 is more prominent in the retina and intestinal mucosal cells 1. Drug created on September 16, 2015 20:56 / Updated on February 21, 2021 18:52, Accelerate your drug discovery research with our fully connected ADMET dataset, With our commercial data, access important information on, Our Blackbox Warnings cover Risks, Contraindications, and Adverse Effects, Reduce medical errors & improve treatment outcomes with our adverse effects data. After first use of the prefilled pen, you can keep it at room temperature, away from heat and direct light, for up to 28 days. The amount of medicine that you take depends on the strength of the medicine. Somatostatin AnalogsLike natural somatostatin, octreotide inhibits the secretion of GH, insulin, and glucagon. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Somatostatin mediates an analgesic activity by reducing vascular and nociceptive components of inflammation 6. The metabolism of Alpelisib can be decreased when combined with Somatostatin. Drug Interaction Checker. Somatostatin elicits anti-neoplastic actions on various tumours via direct or indirect effects, or a combination of both 4. 1992 Sep;41(9 Suppl 2):7-10. Do not freeze. The following information includes only the average doses of this medicine. Depending on the receptor subtype, signalling cascades involve activation of other downstream targets such as Na+/H+ exchanger, Rho GTPase, and nitric oxide synthase (NOS) 1. 362, 372, 377, 394-395, 412, 522). [, Carlton SM, Du J, Davidson E, Zhou S, Coggeshall RE: Somatostatin receptors on peripheral primary afferent terminals: inhibition of sensitized nociceptors. Check with your doctor immediately if any of the following side effects occur: Some side effects may occur that usually do not need medical attention. Be sure that you understand how to use the medicine. Throw away used needles in a hard, closed container that the needles cannot poke through. Therapeutic Class: Endocrine-Metabolic Agent, Pharmacologic Class: Somatostatin (class). If you have any questions, ask your doctor. Octreotide is a long-acting analogue of somatostatin that inhibits the release of a number of hormones, and is clinically used to relieve symptoms of uncommon gastroenteropancreatic endocrine tumours, as well as treat acromegaly 9. [, Marbach P, Briner U, Lemaire M, Schweitzer A, Terasaki T: From somatostatin to sandostatin: pharmacodynamics and pharmacokinetics. Pharmacologic Class: Somatostatin (class) Uses for Sandostatin Octreotide injection is used to treat severe diarrhea and other symptoms that occur with certain intestinal tumors or metastatic carcinoid tumors (tumors that has already spread in the body). For non-prescription products, read the label or package ingredients carefully. Somatostatin is an endogenous peptide hormone that is secreted by the central nervous system, gastrointestinal tract, retina, peripheral neurons and pancreatic D cells of the islets of Langerhans. Class Summary Somatostatin, an orphan drug, is a naturally occurring tetradecapeptide isolated from the hypothalamus and from pancreatic and enteric epithelial cells. Before you have any medical tests, tell the medical doctor in charge that you are using this medicine. Do not double doses. Sandostatin is a hormone drug that is used to treat some types of cancer. Use a different body area each time you give yourself a shot. For this medicine, the following should be considered: Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. However, elderly patients are more likely to have age-related kidney, liver, or heart problems, which may require caution and an adjustment in the dose for patients receiving octreotide injection. Formulary Information Somatostatin has been used in the clinical setting for the diagnosis of acromegaly and gastrointestinal tract tumours. Somatostatin AnalogsMay control symptoms by suppressing secretion of gastroenteropancreatic peptides including insulin. Pharmacol Ther. Some neuroendocrine tumours (NETs) make large amounts of hormones that cause a group of symptoms called carcinoid syndrome. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Other side effects not listed may also occur in some patients. On primary afferent neurons, somatostatin reduces the responses to thermal stimulation in C-mechanoheat sensitive fibers in a dose-dependent fashion and reduces the responses of C-mechanoheat fibers to bradykinin-induced excitation and sensitization to heat 6. It exhibits several biological roles but predominantly exerts an inhibitory effect on secretion of other hormones and transmitters . Do not save an opened ampul or vial or prefilled pen. In conclusion, somatostatin analogs are a promising class of compounds for diagnosis and treatment of cancer. Sandostatin is used to treat acromegaly. Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. This drug is related to the tricyclic antidepressants but has little central nervous effect because of its hydrophilic nature, and offers a degree of specificity for gastric muscarinic receptors. Drug images are also included. If you think your blood pressure is too high or if your heartbeat is too slow, call your doctor right away. If you miss a dose of this medicine, take it as soon as possible. Somatostatin release is inhibited by the Vagus nerve. Adrenal gland: It inhibits angiotensin II-stimulated aldosterone secretion and acetylcholine-induced medullary catecholamine secretion 1. Make sure you tell your doctor if you have any other medical problems, especially: This section provides information on the proper use of a number of products that contain octreotide. If you use this medicine at home, you will be shown the body areas where this shot can be given. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Inflammatory cells and sensory nerves: The expression of somatostatin has been found in inflammatory cells such as lymphocytes, monocytes, macrophages and endothelial cells to act as an autocrine or paracrine regulator in local immune responses. This is not a complete list of Somatostatindrug interactions. Some drugs are prescribed for multiple conditions. The actions of somatostatin are mediated via signalling pathways of G protein-coupled somatostatin receptors. It inhibits the release of growth hormone from the anterior pituitary, and insulin and glucagon from the pancreas. This medicine is available only with your doctor's prescription. Safety and efficacy have not been demonstrated. Somatostatin Accession Number DB09099 Description. Read them carefully and make sure you understand them before using this medicine. GI hemorrhage 3.5 mcg/kg body wt as bolus inj given after the start of continuous infusion & another bolus 1 min before endoscopy.Fistulae or excessive secretion from endocrine tumors Healing is expected 7-14 days. A study of the matrigel sponge assay suggests that through SSTR3-mediated inhibition of both NOS and MAPK activities may lead to the antitumor effects of somatostatin in inhibiting tumor angiogenesis 8. This is a decision you and your doctor will make. 2003 Apr;144(4):1574-84. doi: 10.1210/en.2002-220949. Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of the long-acting form of octreotide injection in children 6 to 17 years of age. If you notice a change in the results of your blood sugar test or urine sugar test, check with your doctor. A nurse or other trained health professional may give you this medicine. Your doctor will adjust your dose as needed. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. With the exception of SSTR3, activation of SSTRs lead to activation of voltage-gated potassium channels accompanied by increased K+ currents. Effects of SSTR3: Activation of these receptors lead to reduction in cell proliferation 1. [, Florio T, Morini M, Villa V, Arena S, Corsaro A, Thellung S, Culler MD, Pfeffer U, Noonan DM, Schettini G, Albini A: Somatostatin inhibits tumor angiogenesis and growth via somatostatin receptor-3-mediated regulation of endothelial nitric oxide synthase and mitogen-activated protein kinase activities. The metabolism of Acalabrutinib can be decreased when combined with Somatostatin. Upon activation, SSTR5 signalling cascades exert an inhibitory action on growth hormone, adrenocorticotropin, insulin, and glucagon-like peptide-1 as well as the secretion of amylase 1. Throw away any unused medicine after 14 days. Studies indicate that somatostatin may be present in nociceptive DRG neurons with C-fibers and primary afferent neurons to inhibit the release of transmitters at the presynaptic junctions of the sensory-efferent nerve terminals 1. The absence of an interaction does not necessarily mean no interactions exist. Antineoplastic effects and potential uses of somatostatin on various tumours, including pituitary adenomas, GEP-NETs, paragangliomas, carcinoids, breast cancers, malignant lymphoma and small-cell lung cancers, have been extensively investigated 1. Other problems, such as arthritis, can also develop. The half-life of endogenous somatostatin is 1-3 minutes due to rapid degradation by peptidase enzymes present in the plasma and tissues 1. 2015 Aug;152:98-110. doi: 10.1016/j.pharmthera.2015.05.007. This vasoconstriction is though the be responsible for reducing blood flow to the esophageal tissues and so reduces bleeding from esophageal varices 2. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. This may cause chest pain or discomfort, headaches, dizziness, or blurred vision. Somatostatin is produced in our bodies, including in the hypothalamus, and exerts a negative impact on certain cellular processes. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Somatostatin(Eklivan) generic is a peptide hormone, prescribed for gastrointestinal hemorrhage. Because its half-life is longer than somatostatin, pasireotide can be used clinically to treat neuroendocrine pituitary tumors that secrete excessive amounts of growth hormone … Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. Gastrointestinal hormones, such as gastrin, secretin, and cholecystokinin (CCK), as well as growth hormones and growth factors are thought to be elevated in gastrointestinal tract and neuroendocrine tumours and are inhibited by somatostatin 4. 2002 Dec;13(10):451-7. Data sources include IBM Watson Micromedex (updated 3 Mar 2021), Cerner Multum™ (updated 1 Mar 2021), ASHP (updated 3 Mar 2021) and others. For short-acting injection dosage form (solution): Adults—At first, 50 micrograms (mcg) given as a shot under the skin 3 times a day. Note: Popularity is based on total prescriptions for the brand and generic versions of each drug, regardless of the condition being treated. [, Lamberts SW, de Herder WW, Hofland LJ: Somatostatin analogs in the diagnosis and treatment of cancer. Talk to your doctor about effective birth control. 2004 Sep 10;574(1-3):55-61. doi: 10.1016/j.febslet.2004.07.084. Using this medicine with any of the following medicines is not recommended. Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. [, Reubi JC, Laissue J, Krenning E, Lamberts SW: Somatostatin receptors in human cancer: incidence, characteristics, functional correlates and clinical implications. Build effective decision support tools with the industry’s most comprehensive, Easily connect various identifiers back to our datasets, InChI=1S/C76H104N18O19S2/c1-41(79)64(100)82-37-61(99)83-58-39-114-115-40-59(76(112)113)92-72(108)57(38-95)91-75(111)63(43(3)97)94-71(107)54(33-46-23-11-6-12-24-46)90-74(110)62(42(2)96)93-66(102)51(28-16-18-30-78)84-69(105)55(34-47-36-81-49-26-14-13-25-48(47)49)88-68(104)53(32-45-21-9-5-10-22-45)86-67(103)52(31-44-19-7-4-8-20-44)87-70(106)56(35-60(80)98)89-65(101)50(85-73(58)109)27-15-17-29-77/h4-14,19-26,36,41-43,50-59,62-63,81,95-97H,15-18,27-35,37-40,77-79H2,1-3H3,(H2,80,98)(H,82,100)(H,83,99)(H,84,105)(H,85,109)(H,86,103)(H,87,106)(H,88,104)(H,89,101)(H,90,110)(H,91,111)(H,92,108)(H,93,102)(H,94,107)(H,112,113)/t41-,42+,43+,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,62-,63-/m0/s1, (4R,7S,10S,13S,16S,19S,22S,25S,28S,31S,34S,37R)-19,34-bis(4-aminobutyl)-37-{2-[(2S)-2-aminopropanamido]acetamido}-13,25,28-tribenzyl-31-(carbamoylmethyl)-10,16-bis[(1R)-1-hydroxyethyl]-7-(hydroxymethyl)-22-[(1H-indol-3-yl)methyl]-6,9,12,15,18,21,24,27,30,33,36-undecaoxo-1,2-dithia-5,8,11,14,17,20,23,26,29,32,35-undecaazacyclooctatriacontane-4-carboxylic acid, C[C@@H](O)[C@@H]1NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC2=CNC3=C2C=CC=C3)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CO)NC1=O)C(O)=O)NC(=O)CNC(=O)[C@H](C)N)[C@@H](C)O, Accelerate your drug discovery research with our ADMET & drug target dataset, Power your clinical software with the most comprehensive allergy info on the market, Postoperative Complications caused by Pancreatic Surgery, H01 — PITUITARY AND HYPOTHALAMIC HORMONES AND ANALOGUES, H — SYSTEMIC HORMONAL PREPARATIONS, EXCL.
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