This site complies with the HONcode standard for trustworthy health information: verify here. Wright JM, Sachdev PS, Perkins RJ, Rodriguez P "Zidovudine-related mania." 9. Last updated on July 6, 2020. 1. It is either used by itself or along with other antiretrovirals. Available for Android and iOS devices. SaintMarc T, Partisani M, PoizotMartin I, Bruno F, Rouviere O, Lang JM, Gastaut JA, Touraine JL "A syndrome of peripheral fat wasting (Lipodystrophy) in patients receiving long-term nucleoside analogue therapy." epivir. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. In the early symptomatic HIV disease study, nausea (61%), vomiting (25%), and dyspepsia (6%) were reported with zidovudine. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. In this study, back pain, arthralgia, muscle spasm, twitch, and myopathy were reported in less than 5% of patients using zidovudine. Other side effects include: neutropenia. [Ref], -Frequency not reported: Urinary hesitancy, dysuria, polyuria[Ref]. (4/8/2015): 6. Retrovir (zidovudine)." It contains lamivudine, nevirapine, and stavudine. Med J Aust 150 (1989): 339-40, 19. Portions of this document last updated: Feb. 01, 2021. 8. Tell your doctor if you have unlikely but serious side effects of Combivir including: mental/mood changes (such as depression), signs of pancreatitis (such as vomiting, stomach/abdominal/ back pain, fever), easy bruising or bleeding, or At least 1 case of macular edema was deemed definitively associated with zidovudine in a patient with history of anterior uveitis secondary to syphilis. Dalakas MC, Illa I, Pezeshkpour GH, et al "Mitochondrial myopathy caused by long-term zidovudine therapy." hypertriglyceridaemia, hypercholesterolaemia, insulin resistance, hyperglycaemia, hyperlactataemia), osteonecrosis; … Drug information provided by: IBM Micromedex. pains in the stomach, side, or abdomen, possibly radiating to the back pinpoint red spots on the skin puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue right upper abdominal or stomach pain and fullness Check out these best-sellers and special offers on books and newsletters from Mayo Clinic. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. "Product Information. Learn more about Dolutegravir & Abacavir & Lamivudine Although rare, they may require the immediate termination of the drug and, in some cases, emergency medical intervention. In an advanced HIV disease study, headache (42%), somnolence (8%), dizziness (6%), paresthesia … Hepatic function should be monitored closely with both clinical and laboratory follow-up for at least several months in patients who discontinue lamivudine / zidovudine and are co-infected with HIV-1 and HBV. Lamivudine / 3TC TABLETS AND ORAL SOLUTION. A rare and potentially fatal condition called lactic acidosis can develop in patients taking lamivudine. Side effects and tolerability of post-exposure prophylaxis with zidovudine, lamivudine, and lopinavir/ritonavir: a comparative study with HIV/AIDS patients Chin Med J (Engl). You may report side effects to FDA at 1-800-FDA-1088. [Ref], Very common (10% or more): Musculoskeletal pain (up to 13.5%), Postmarketing reports: Muscle weakness, elevated creatine phosphokinase (CPK), rhabdomyolysis, -Common (1% to 10%): Arthralgia, muscle disorders, -Common (1% to 10%): Musculoskeletal pain, myalgia, -Frequency not reported: Symptomatic myopathy, myositis, back pain, arthralgia, muscle spasm, twitch, -Frequency not reported: Osteonecrosis[Ref]. AIDS 5 (1991): 1395-6, 25. Health Canada. Elevated ALT (greater than 5 x ULN), AST (greater than 5 x ULN), and bilirubin (greater than 2.5 x ULN) have been reported in 3.7%, 1.7%, and 0.8% of patients using lamivudine plus zidovudine, respectively, and 3.6%, 1.8%, and 0.4% of patients using zidovudine, respectively. Truvada, tenofovir, lamivudine, emtricitabine, Atripla, Stribild, Complera, Epzicom. Granulocytopenia (less than 750/mm3) has been reported in 6.4% (CD4 up to 500 using 1500 mg), 1.8% (CD4 up to 500 using 500 mg), 4% (CD4 greater than 200 using 1200 mg), 10% (CD4 greater than 200 using 1500 mg), and 47% (CD4 less than 200 using 1500 mg) of patients using zidovudine. These side effects may go away during treatment as your body adjusts to the medicine. In this study, redistribution/accumulation of body fat was reported in less than 5% of patients using zidovudine. There are several side effects associated with Epzicom that can be severe and even life-threatening. Lamivudine affects your immune system, which may cause certain side effects (even weeks or months after you've taken this medicine). Many other medications may also interact with lamivudine and zidovudine, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list. Take efavirenz, lamivudine, and tenofovir exactly as directed. Tell your doctor if you have: signs of a new infection --fever, night sweats, swollen glands, cold sores, cough, wheezing, diarrhea, weight loss; Brinkman K, terHofstede HJM, Burger DM, Smeitinkt JAM, Koopmans PP "Adverse effects of reverse transcriptase inhibitors: mitochondrial toxicity as common pathway." AIDS 21 (2007): 268-269, 11. It is much better tolerated than interferon. Epivir (lamivudine)." One patient with preexisting hepatitis B developed acute hepatic failure 2 weeks after starting zidovudine therapy. Side effects have been reported with lamivudine and zidovudine, administered separately or together. Dubin G, Braffman MN "Zidovudine-induced hepatotoxicity." Pharmacokinetics: Absorption: Rapidly absorbed from the GI tract.Delayed absorption by ingestion w/ food. As of 2019, it is listed by the World Health Organization (WHO) as the first line treatment for adults with HIV/AIDS, with tenofovir/lamivudine/efavirenz as an alternative. You may report them to the FDA. In this study, anxiety, confusion, depression, emotional lability, nervousness, and loss of mental acuity were reported in less than 5% of patients using zidovudine. Along with its needed effects, lamivudine / zidovudine may cause some unwanted effects. In an advanced HIV disease study, nausea (46%), GI pain (20%), diarrhea (12%), vomiting (6%), and dyspepsia (5%) were reported with zidovudine; only nausea was reported at a significantly greater rate than placebo. Discontinue lamivudine / zidovudine if clinical or laboratory findings suggestive of lactic acidosis or pronounced hepatotoxicity occur.Severe acute exacerbations of hepatitis B have been reported in patients who are co-infected with hepatitis B virus (HBV) and HIV-1 and have discontinued lamivudine. O 0, 4. Panel on Antiretroviral Guidelines for Adults and Adolescents "Guidelines for the use of antiretroviral In this study, chills, influenza syndrome, and chest pain were reported in less than 5% of patients using zidovudine. Torres RA, Lin RY, Lee M, Barr MR "Zidovudine-induced leukocytoclastic vasculitis." "New once-daily HIV combination better tolerated." Lactic acidosis and severe hepatomegaly with steatosis (including fatal cases) have been reported with the use of nucleoside analogs. pregnancy, upcoming surgery, etc. ), allergies, pre-existing diseases, and current health conditions (e.g. This content does not have an English version. Expert Rev Anti Infect Ther 2 (2004): 826, 24. Many people using this medication do not have serious side effects. Headache, tiredness, loss of appetite, nausea, vomiting, diarrhea, trouble sleeping, dizziness, or stuffy nose may occur. Along with its needed effects, a medicine may cause some unwanted effects. Lamivudine side effects. J Intern Med 231 (1992): 317-8, 21. Neutropenia (absolute neutrophil count less than 750/mm3), anemia (hemoglobin less than 8 g/dL), and thrombocytopenia (platelets less than 50,000/mm3) have been reported in 7.2%, 2.9%, and 0.4% of patients using lamivudine plus zidovudine, respectively, and 5.4%, 1.8%, and 1.3% of patients using zidovudine, respectively. Rabaud C, Burty C, Grandidier M, et al. [Ref], In an advanced HIV disease study, insomnia (5%) was reported with zidovudine at a significantly greater rate than placebo. Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Continuous Professional Development, Mayo Clinic School of Graduate Medical Education, FREE book offer — Mayo Clinic Health Letter, Time running out - 40% off Online Mayo Clinic Diet ends soon. In an asymptomatic HIV infection study, anorexia was reported in 19.3% (using 1500 mg) and 20.1% (using 500 mg) of patients using zidovudine. Zidovudine has been associated with hematologic toxicity (including neutropenia and severe anemia), particularly in patients with advanced HIV-1 disease. Lamivudine/Zidovudine Side Effects See also Warning section. Minor side effects may include nausea, fatigue, headaches, diarrhea, cough and nasal congestion. Lamivudine Side Effects See also Warning section. Sahai J, Conway B, Cameron D, Garber G "Zidovudine-associated hypertrichosis and nail pigmentation in an HIV-infected patient." Bluish or brownish-black discoloration of nails has developed during the first 1 or 2 months of zidovudine therapy and usually disappeared within 2 months if the drug is discontinued. Dose reduction has not affected the course of myopathy, although drug discontinuation sometimes resulted in improvement of symptoms, generally within a month. Get medical help right away if you have any of the following serious symptoms, including: symptoms of liver problems (such as … Exacerbation of anemia has been reported in HIV-1/HCV-coinfected patients using zidovudine and ribavirin. McLeod GX, Hammer SM "Zidovudine: five years later." Am J Med 86 (1989): 469-70, 26. Anemia, neutropenia, and leukopenia were reported more often with higher doses (1200 to 1500 mg/day) and in patients with advanced HIV disease (especially with poor bone marrow reserve at baseline) and particularly in those with CD4 cell counts less than 100/mm3. In the early symptomatic HIV disease study, asthenia was reported in 69% of patients using zidovudine. In an advanced HIV disease study, headache (42%), somnolence (8%), dizziness (6%), paresthesia (6%), and taste perversion (5%) were reported with zidovudine; only headache was reported at a significantly greater rate than placebo. 7. Data sources include IBM Watson Micromedex (updated 3 Mar 2021), Cerner Multum™ (updated 1 Mar 2021), ASHP (updated 3 Mar 2021) and others. Piacenti FJ "An update and review of antiretroviral therapy." [Ref], Postmarketing reports: Cardiomyopathy, vasculitis, -Frequency not reported: Vasodilation[Ref], Frequency not reported: Immune reconstitution/reactivation syndrome, autoimmune disorders in the setting of immune reconstitution (e.g., Graves' disease, polymyositis, Guillain-Barre syndrome), Frequency not reported: Disturbances of vision, -Frequency not reported: Amblyopia, photophobia, macular edema[Ref]. In this study, constipation, dysphagia, tongue edema, eructation, flatulence, bleeding gums, rectal hemorrhage, lip edema, and mouth ulcer were reported in less than 5% of patients using zidovudine. Rarely, lamivudine has caused severe (sometimes fatal) liver problems and a buildup of lactic acid in the blood (lactic acidosis). Incidence was higher in patients with mild laboratory abnormalities at baseline. In fact, in at least one trial, the lamivudine had fewer side effects than the placebo pills. It is taken by mouth twice a day. This content does not have an Arabic version. [Ref], Common (1% to 10%): Anorexia and/or decreased appetite, Postmarketing reports: Hyperglycemia, redistribution/accumulation of body fat, lactic acidosis, -Very rare (less than 0.01%): Lactic acidosis, -Postmarketing reports: Hyperlactatemia (common), lactic acidosis (rare), redistribution/accumulation of body fat, -Rare (0.01% to 0.1%): Lactic acidosis (without hypoxemia), -Frequency not reported: Redistribution/accumulation of body fat, hyperlactatemia, -Frequency not reported: Redistribution/accumulation of body fat (including central obesity, dorsocervical fat enlargement, peripheral wasting, facial wasting, breast enlargement, "cushingoid appearance"), increased blood lipid levels, increased glucose levels[Ref], Common (1% to 10%): Skin rashes, sweating, fungal skin infection, acne and folliculitis, viral skin infection, Postmarketing reports: Alopecia, erythema multiforme, Stevens-Johnson syndrome, urticaria, -Common (1% to 10%): Sweating/diaphoresis, fungal skin infection, acne and folliculitis, viral skin infection, -Rare (0.01% to 0.1%): Nail and skin pigmentation, urticaria, -Frequency not reported: Lipoatrophy, skin and nailbed pigmentation changes, toxic epidermal necrolysis, leukocytoclastic vasculitis (with eosinophilia and fever), nail hyperpigmentation (rarely accompanied by mucocutaneous pigmentation or hypertrichosis), body odor[Ref]. Available from: URL: https://aidsinfo.nih.gov/contentfiles/lvguidelines/adultandadolescentgl.pdf." In an advanced HIV disease study, anorexia (11%) was reported with zidovudine. If you notice any other effects, check with your healthcare professional. AIDS 17 (2003): 1988-90, 23. Don P, Fusco F, Fried P, et al "Nail dyschromia associated with zidovudine." Mayo Clinic facts about coronavirus disease 2019 (COVID-19), Our COVID-19 patient and visitor guidelines, plus trusted health information, Mayo Clinic Health System patient vaccination updates. Although not all of these side effects may occur, if they do occur they may need medical attention. Aids 14 (2000): 1309-16, 13. Commonly reported side effects of lamivudine/zidovudine include: nausea and nausea and vomiting. Cerner Multum, Inc. "UK Summary of Product Characteristics." Myopathy and myositis (with pathological changes similar to that produced by HIV-1 disease) have been associated with prolonged zidovudine use. Gradon JD, Chapnick EK, Sepkowitz DV "Zidovudine-induced hepatitis." For many of these side effects, it was not clear if they were due to lamivudine, zidovudine, the other drugs used to treat HIV infection, or the underlying disease process.[Ref]. The most common side effects of DOVATO include: headache; nausea; diarrhea; trouble sleeping; tiredness; anxiety; These are not all the possible side effects of DOVATO. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. [Ref], In an advanced HIV disease study, vasodilation was reported in less than 5% of patients using zidovudine. 1. Common Questions and Answers about Lamivudine side effects. Occasionally, neutropenia and anemia reported with lamivudine were severe. Serious side effects can occur with lamivudine use. Side effects may include trouble sleeping and weight gain. All rights reserved. It may be used in people with both HIV and tuberculosis, however if the person is on rifampicin a larger dose of dolutegravir is needed.. Side effects. Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. agents in HIV-1-infected adults and adolescents. Combivir (lamivudine-zidovudine)" Glaxo Wellcome, Research Triangle PK, NC. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. O'Dowd MA, McKegney FP "Manic syndrome associated with zidovudine." © 1998-2021 Mayo Foundation for Medical Education and Research (MFMER). In an asymptomatic HIV infection study, headache and dizziness were reported in 58% and 20.8% (using 1500 mg) and 62.5% and 17.9% (using 500 mg) of patients using zidovudine, respectively. side-effects and special precautions Side-effects: The following side-effects have been reposed during therapy of HIV disease with LAMIVUDINE alone, and in combination with other anti-retrovirals. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Other side effects not listed may also occur in some patients. It is on the World Health Organization's List of Essential Medicines. Mayo Clinic does not endorse companies or products. Lamivudine/nevirapine/stavudine (3TC/NVP/d4T) is a fixed-dose combination antiretroviral medication used to treat HIV/AIDS. Mallal SA, John M, Moore CB, James IR, McKinnon EJ "Contribution of nucleoside analogue reverse transcriptase inhibitors to subcutaneous fat wasting in patients with HIV infection." Incidence of neutropenia increased in patients with low neutrophil counts, hemoglobin levels, and serum vitamin B12 levels at baseline. Elevated amylase (greater than 2 times the upper limit of normal [2 x ULN]) has been reported in 4.2% of patients using lamivudine plus zidovudine and 1.5% of patients using zidovudine. Herskowitz A, Willoughby SB, Baughman KL, et al "Cardiomyopathy associated with antiretroviral therapy in patients with HIV infection: a report of six cases." It has very few side effects. Redistribution/accumulation of body fat has been reported with antiretroviral therapy; causality has not been established. Abdominal pain, nausea, vomiting, diarrhoea, headache, fever, rash, alopecia, malaise, insomnia, cough, nasal symptoms, arthralgia, musculoskeletal pain, pancreatitis, anaemia, neutropenia, thrombocytopenia, immune reconstitution syndrome, lipodystrophy, metabolic abnormalities (e.g. Ann Intern Med 110 (1989): 85-6, 22. Some side effects may occur that usually do not need medical attention. "Product Information. "Product Information. 2014;127(14):2632-6. Anemia (hemoglobin less than 8 g/dL) has been reported in 6.4% (CD4 up to 500 using 1500 mg), 1.1% (CD4 up to 500 using 500 mg), 4% (CD4 greater than 200 using 1200 mg), 3% (CD4 greater than 200 using 1500 mg), and 29% (CD4 less than 200 using 1500 mg) of patients using zidovudine. Applies to lamivudine/zidovudine: oral tablet. JAMA 260 (1988): 3587-8, 18. Serious side effects and their symptoms can include the following: Lactic acidosis or severe liver enlargement. … Lamivudine (3tc) (Epivir; Epivir HBV) is a drug prescribed for the treatment of HIV infection and hepatitis B infection. Advertising revenue supports our not-for-profit mission. License: Except as otherwise noted, this work is licensed under a Creative Commons Attribution-Noncommercial-Share Alike 4.0 License.For commercial use or customized versions, please contact biobyte solutions GmbH.. Disclaimer: The content of this database of side effects (adverse drug reactions) is intended for educational and scientific research purposes only. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Anders KH, Abele DC "Development of nail pigmentation during zidovudine therapy." In 1 zidovudine study, myalgias and elevated CPK occurred in 8% of treated patients with a CD4 cell count less than 200/mm3, and in none of the patients with higher CD4 cell counts. In an advanced HIV disease study, asthenia (19%), fever (16%), and malaise (8%) were reported with zidovudine. Schedule your appointment now for safe in-person care. Discoloration has occurred as longitudinal streaks or transverse bands. Check with your doctor immediately if any of the following side effects occur while taking lamivudine / zidovudine: Some side effects of lamivudine / zidovudine may occur that usually do not need medical attention. [Ref], Very common (10% or more): Headache (up to 35.1%), neuropathy (up to 12.4%), dizziness (up to 10.4%), Frequency not reported: Syncope, taste perversion, Postmarketing reports: Paresthesia, peripheral neuropathy, seizures, -Rare (0.01% to 0.1%): Peripheral neuropathy/neuropathy, paresthesia, -Very common (10% or more): Headache, dizziness, -Common (1% to 10%): Neuropathy, paresthesia, somnolence, taste perversion, -Frequency not reported: Generalized seizures, status epilepticus, vertigo, Wernicke's syndrome, hearing loss, hyperalgesia, tremor, syncope[Ref], Very common (10% or more): Nausea (33%), diarrhea (18%), nausea and vomiting (13%), abdominal discomfort and pain (up to 11.3%), Common (1% to 10%): Abdominal cramps, dyspepsia, elevated amylase, fungal gastrointestinal (GI) infection, GI discomfort and pain, gaseous symptoms, vomiting, Postmarketing reports: Oral mucosal pigmentation, stomatitis, pancreatitis, -Common (1% to 10%): Nausea, vomiting, abdominal discomfort and pain or cramps, diarrhea, -Uncommon (0.1% to 1%): Pancreatitis, abnormal pancreatic enzymes, -Rare (0.01% to 0.1%): Elevated serum amylase, -Very common (10% or more): Nausea, GI pain, diarrhea, vomiting, -Common (1% to 10%): Abdominal discomfort and pain, fungal GI infection, GI discomfort and pain, gaseous symptoms, elevated amylase, dyspepsia, -Rare (0.01% to 0.1%): Oral mucosa pigmentation, pancreatitis, -Frequency not reported: Constipation, dysphagia, tongue edema, eructation, bleeding gums, rectal hemorrhage, lip edema, mouth ulcer[Ref]. ).Some health conditions may make you more susceptible to the side-effects of the drug. Tell your doctor if … For Healthcare Professionals General. Do not take more or less of it or take it more often than prescribed by your doctor. See below for a comprehensive list of adverse effects. N Engl J Med 354 (2006): 251-60. Side effects: 77. In an advanced HIV disease study, lymphadenopathy was reported in less than 5% of patients using zidovudine.[Ref]. Although not all of these side effects may occur, if they do occur they may need medical attention. [Ref], Common (1% to 10%): Elevated ALT, elevated AST, abnormal liver function tests, Uncommon (0.1% to 1%): Elevated bilirubin, Frequency not reported: Severe hepatomegaly with steatosis, hepatic decompensation, Postmarketing reports: Hepatic steatosis, posttreatment exacerbation of hepatitis B, -Uncommon (0.1% to 1%): Elevated liver enzymes (AST, ALT), -Rare (0.01% to 0.1%): Hepatitis, abnormal liver function tests, -Common (1% to 10%): Elevated liver enzyme levels in blood (including ALT, AST), elevated bilirubin levels in blood, -Rare (0.01% to 0.1%): Liver disorders (e.g., severe hepatomegaly with steatosis), -Frequency not reported: Changes in liver function tests (including increased AST levels), acute hepatic failure[Ref], Common (1% to 10%): Neutropenia, anemia, lymphatic signs/symptoms, decreased white cells, Postmarketing reports: Anemia (including pure red cell aplasia and anemias progressing on therapy), lymphadenopathy, splenomegaly, -Uncommon (0.1% to 1%): Neutropenia, anemia, thrombocytopenia, decreased white cells, -Very rare (less than 0.01%): Pure red cell aplasia, -Very common (10% or more): Granulocytopenia, anemia, -Common (1% to 10%): Neutropenia, leukopenia, lymphatic signs/symptoms, decreased white cells, thrombocytopenia, -Uncommon (0.1% to 1%): Pancytopenia (with marrow hypoplasia), -Rare (0.01% to 0.1%): Pure red cell aplasia, -Very rare (less than 0.01%): Aplastic anemia, -Frequency not reported: Exacerbation of anemia, hemolytic anemia, hematologic toxicity (including neutropenia, severe anemia), lymphadenopathy[Ref]. 5. Am J Med 86 (1989): 814-8, 15. O 0, 3. Drug interactions, and dosage, and pregnancy and breastfeeding safety information should be reviewed prior to taking this medication. Clin Infect Dis 40 (2005): 303-5, 10. N Engl J Med 322 (1990): 1098-105, 16. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. Taking efavirenz, lamivudine, and tenofovir at bedtime may make certain side effects less bothersome. [Ref], Very common (10% or more): Insomnia and other sleep disorders (up to 11.6%), -Common (1% to 10%): Sleep disorders, insomnia, -Rare (0.01% to 0.1%): Anxiety, depression, loss of mental acuity, -Frequency not reported: Mania, confusion, grandiosity, emotional lability, nervousness[Ref]. All rights reserved. In this study, seizures, vertigo, hearing loss, hyperalgesia, tremor, and syncope were reported in less than 5% of patients using zidovudine. Arch Intern Med 151 (1991): 981-6, 17. Description: Lamivudine, a synthetic nucleoside analogue, is phosphorylated into the body to the active 5'-triphosphate metabolite.It inhibits RNA- and DNA-dependent polymerase activities of reverse transcriptase via DNA chain termination. Zidovudine has been associated with hematologic toxicity including neutropenia and severe anemia, particularly in patients with advanced Human Immunodeficiency Virus (HIV-1) disease.Prolonged use of zidovudine has been associated with symptomatic myopathy.Lactic acidosis and severe hepatomegaly with steatosis, including fatal cases, have been reported with the use of nucleoside analogues, including lamivudine and zidovudine. Abacavir and lamivudine can also cause serious or fatal side effects on the liver. Department of Health and Headache, dizziness, nausea, diarrhea, or trouble sleeping may occur. Gastro-intestinal disorders: Pancreatitis, upper abdominal pain, … In an advanced HIV disease study, rash (17%) and diaphoresis (5%) were reported with zidovudine. Call your doctor for medical advice about side effects. Muscle biopsy has shown atrophic and sometimes necrotic fibers, ragged-red fibers, and large accumulations of mitochondrial and fibrillar sarcoplasmic inclusions. Some side effects may not be reported. Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. If appropriate, initiation of anti-hepatitis B therapy may be warranted. Gallant JE, DeJesus E, Arribas JR, et al "Tenofovir DF, emtricitabine, and efavirenz vs. zidovudine, lamivudine, and efavirenz for HIV." Lamivudine and zidovudine affects your immune system, which may cause certain side effects (even weeks or months after you've taken this medicine). Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Applies to lamivudine / zidovudine: oral tablet, Side effects have been reported with lamivudine and zidovudine, administered separately or together. In an advanced HIV disease study, myalgia (8%) was reported with zidovudine at a significantly greater rate than placebo. AIDS 13 (1999): 1659-67, 14. Many people using this medication do not have serious side effects. "Tolerability of postexposure prophylaxis with the combination of zidovudine-lamivudine and lopinavir-ritonavir for HIV infection." Merenich JA, Hannon RN, Gentry RH, Harrison SM "Azidothymidine-induced hyperpigmentation mimicking primary adrenal insufficiency."
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